{"id":67,"date":"2015-11-05T14:01:56","date_gmt":"2015-11-05T16:01:56","guid":{"rendered":"http:\/\/skinage.medicina.ufmg.br\/?page_id=35"},"modified":"2021-02-23T13:13:19","modified_gmt":"2021-02-23T16:13:19","slug":"scientific-papers","status":"publish","type":"page","link":"https:\/\/skinage.medicina.ufmg.br\/index.php\/en\/scientific-papers\/","title":{"rendered":"Scientific Papers"},"content":{"rendered":"<p><strong>JMIR Publications (Research Article)<\/strong><br \/>\n14\u00a0de julho de\u00a02020 \u2013 Toronto\u2013\u00a0Canada<\/p>\n<hr \/>\n<h3>Premature or Small for Gestational Age Discrimination: International Multicenter Trial Protocol for Classification of the Low-Birth-Weight Newborn Through the Optical Properties of the Skin<\/h3>\n<p>Zilma Reis, Gabriela Vitral, Rodney Guimar\u00e3es, Juliano Gaspar, Enrico Colosimo, Sergio Taunde, Nilza Mussagy, Rita Rosado Santos, Diogo Ayres-De-Campos, Roberta Romanelli<\/p>\n<p><a href=\"http:\/\/skinage.medicina.ufmg.br\/wp-content\/uploads\/2018\/05\/journal.pone_.0196542-Print-72dpi.pdf\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-226\" src=\"http:\/\/skinage.medicina.ufmg.br\/wp-content\/uploads\/2015\/11\/kilavuz1-1-e1490710271991.png\" alt=\"\" width=\"30\" height=\"30\" \/><\/a>\u00a0\u00a0<a href=\"http:\/\/skinage.medicina.ufmg.br\/wp-content\/uploads\/2021\/02\/Premature-or-Small-for-Gestational-Age-Discrimination.pdf\">Abrir PDF<\/a><\/p>\n<p><strong>Abstract<br \/>\n<\/strong><\/p>\n<p><strong>Background<\/strong><\/p>\n<div id=\"section1\" class=\"section toc-section\">\n<p>A low birth weight is an independent risk factor for adverse infant outcomes and a predictor of chronic disease in adulthood. In these situations, differentiating between prematurity and small for gestational age (SGA) or simultaneous conditions is essential to ensuring adequate care. Such diagnoses, however, depend on reliable pregnancy dating, which can be challenging in developing countries. A new medical optoelectronic device was developed to estimate gestational age (GA) at birth based on newborn skin reflection.<\/p>\n<\/div>\n<p><strong>Objective<\/strong><\/p>\n<div id=\"section2\" class=\"section toc-section\">\n<p>This study will aim to evaluate the device\u2019s ability to detect prematurity or SGA, or both conditions simultaneously as well as predict short-term pulmonary complications in a cohort of low-birth-weight newborns.<\/p>\n<\/div>\n<p><strong>Methods<\/strong><\/p>\n<div class=\"abstract toc-section\">\n<div id=\"section3\" class=\"section toc-section\">\n<p>This study protocol was designed for a multicenter cohort including referral hospitals in Brazil and Mozambique. Newborns weighing 500-2500 g will be eligible for inclusion with the best GA available, considering the limited resources of low-income countries. Comparator-GA is based on reliable last menstrual period dating or ultrasound assessment before 24 weeks\u2019 gestation. Estimated GA at birth (Test-GA) will be calculated by applying a novel optoelectronic device to the newborn\u2019s skin over the sole. The average difference between Test-GA and Comparator-GA will be analyzed, as will the percentage of newborns who are correctly diagnosed as preterm or SGA. In addition, in a nested case\u2013control study, the accuracy of skin reflection in the prediction of prematurity-related respiratory problems will be evaluated. The estimated required sample size is 298 newborns.<\/p>\n<\/div>\n<\/div>\n<p><strong>Results<\/strong><\/p>\n<div class=\"abstract toc-section\">\n<div id=\"section3\" class=\"section toc-section\">\n<p>Teams of health professionals were trained, and standard operating procedures were developed following the good practice guidelines for the clinical investigation of medical devices for human participants. The first recruitment started in March 2019 in Brazil. Data collection is planned to end in December 2020, and the results should be available in March 2021.<\/p>\n<\/div>\n<\/div>\n<p><strong>Conclusions<\/strong><\/p>\n<div class=\"abstract toc-section\">\n<div id=\"section3\" class=\"section toc-section\">\n<p>The results of this clinical study have the potential to validate a new device to easily assess postnatal GA, supporting SGA identification when pregnancy dating is unreliable or unknown.<\/p>\n<\/div>\n<\/div>\n<hr \/>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><strong>JMIR Publications (Research Article)<\/strong><br \/>\n14 de julho de\u00a02020 \u2013 Toronto\u2013\u00a0Canada<\/p>\n<hr \/>\n<h3>Pregnant Users\u2019 Perceptions of the Birth Plan Interface in the \u201cMy Prenatal Care\u201d App: Observational Validation Study<\/h3>\n<p>Juliana Moraes Carrilho, Isaias Jos\u00e9 Ramos Oliveira, Dimitri Santos, Gabriel Costa Osanan, Ricardo Jo\u00e3o Cruz-Correia, Zilma Silveira Nogueira Reis<\/p>\n<p><a href=\"http:\/\/skinage.medicina.ufmg.br\/wp-content\/uploads\/2018\/05\/journal.pone_.0196542-Print-72dpi.pdf\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-226\" src=\"http:\/\/skinage.medicina.ufmg.br\/wp-content\/uploads\/2015\/11\/kilavuz1-1-e1490710271991.png\" alt=\"\" width=\"30\" height=\"30\" \/><\/a>\u00a0\u00a0<a href=\"http:\/\/skinage.medicina.ufmg.br\/wp-content\/uploads\/2021\/02\/Pregnant-Users-Perceptions-of-the-Birth-Plan-Interface-in-the-My-Prenatal-Care-App.pdf\">Abrir PDF<\/a><\/p>\n<p><strong>Abstract<br \/>\n<\/strong><\/p>\n<p><strong>Background<\/strong><\/p>\n<div id=\"section1\" class=\"section toc-section\">\n<p>Birth plans are meant to be a declaration of the expectations and preferences of pregnant woman regarding childbirth. The My Prenatal Care app engages pregnant women in an educational intervention for a healthy pregnancy. We hypothesized that users\u2019 positive perception of an in-app birth plan is a relevant step for establishing direct communication between pregnant women and the health care team, based on an online report available on the app.<\/p>\n<\/div>\n<p><strong>Objective<\/strong><\/p>\n<div id=\"section2\" class=\"section toc-section\">\n<p>This study aimed to evaluate pregnant women\u2019s perception about the communicability of birth-plan preparation using a mobile app.<\/p>\n<\/div>\n<p><strong>Methods<\/strong><\/p>\n<div class=\"abstract toc-section\">\n<div id=\"section3\" class=\"section toc-section\">\n<p>This was an observational, exploratory, descriptive study. The methodology was user centered, and both qualitative and quantitative approaches were employed. The tools of the communicability evaluation method were applied. Overall, 11 pregnant women evaluated their experience of using a birth-plan prototype interface. The evaluation was performed in a controlled environment, with authorized video recording. There were 8 task-oriented interactions proposed to evaluate interface communicability with users when using the Birth Plan menu. For evaluating perceptions and experiences, a survey with structured and open-ended questions in addition to the free expression of participants was conducted. The primary outcomes assessed were interface communicability and user\u2019s perception of the Birth Plan prototype interface in the My Prenatal Care mobile app. Secondarily, we involved users in the prototyping phase of the interface to identify bottlenecks for making improvements in the app.<\/p>\n<\/div>\n<\/div>\n<p><strong>Results<\/strong><\/p>\n<div class=\"abstract toc-section\">\n<div id=\"section3\" class=\"section toc-section\">\n<p>Regarding users\u2019 performance in accomplishing previously prepared tasks, we found that 10 of 11 (91%) women were capable of completing at least 6 of 8 (75%) tasks. A positive relationship was found between the number of communicability problems and the success of completing the tasks. An analysis of the records revealed three communicability breakdowns related to the data entry, save, and scrollbar functions. The participants freely expressed suggestions for improvements such as for the save function and the process of sharing the birth-plan form upon completion.<\/p>\n<\/div>\n<\/div>\n<p><strong>Conclusions<\/strong><\/p>\n<div class=\"abstract toc-section\">\n<div id=\"section3\" class=\"section toc-section\">\n<p>Users had a positive perception of the Birth Plan menu of the My Prenatal Care app. This user-centered validation enabled the identification of solutions for problems, resulting in improvements in the app.<\/p>\n<\/div>\n<\/div>\n<hr \/>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><strong>JMIR Publications (Research Article)<\/strong><br \/>\n15\u00a0de abril de\u00a02020 \u2013 Toronto\u2013\u00a0Canada<\/p>\n<hr \/>\n<h3>Quality of Pregnancy Dating and Obstetric Interventions During Labor: Retrospective Database Analysis<\/h3>\n<p>Zilma Silveira Nogueira Reis, Juliano De Souza Gaspar, Gabriela Luiza Nogueira Vitral, Vitor Barbosa Abrantes, Ingrid Michelle Fonseca De-Souza, Maria Tereza Silveira Moreira,Regina Am\u00e9lia Lopes Pessoa Aguiar<\/p>\n<p><a href=\"http:\/\/skinage.medicina.ufmg.br\/wp-content\/uploads\/2018\/05\/journal.pone_.0196542-Print-72dpi.pdf\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-226\" src=\"http:\/\/skinage.medicina.ufmg.br\/wp-content\/uploads\/2015\/11\/kilavuz1-1-e1490710271991.png\" alt=\"\" width=\"30\" height=\"30\" \/><\/a>\u00a0\u00a0<a href=\"http:\/\/skinage.medicina.ufmg.br\/wp-content\/uploads\/2021\/02\/Quality-of-Pregnancy-Dating-and-Obstetric-Interventions-During-Labor.pdf\">Abrir PDF<\/a><\/p>\n<p><strong>Abstract<br \/>\n<\/strong><\/p>\n<p><strong>Background<\/strong><\/p>\n<div id=\"section1\" class=\"section toc-section\">\n<p>The correct dating of pregnancy is critical to support timely decisions and provide obstetric care during birth. The early obstetric ultrasound assessment before 14 weeks is considered the best reference to assist in determining gestational age (GA), with an accuracy of \u00b15 to 7 days. However, this information is limited in many settings worldwide.<\/p>\n<\/div>\n<p><strong>Objective<\/strong><\/p>\n<div id=\"section2\" class=\"section toc-section\">\n<p>The aim of this study is to analyze the association between the obstetric interventions during childbirth and the quality of GA determination, according to the first antenatal ultrasound assessment, which assisted the calculation.<\/p>\n<\/div>\n<p><strong>Methods<\/strong><\/p>\n<div class=\"abstract toc-section\">\n<div id=\"section3\" class=\"section toc-section\">\n<p>This is a hospital-based cohort study using medical record data of 2113 births at a perinatal referral center. The database was separated into groups and subgroups of analyses based on the reference used by obstetricians to obtain GA at birth. Maternal and neonatal characteristics, mode of delivery, oxytocin augmentation, and forceps delivery were compared between groups of pregnancies with GA determination at different reference points: obstetric ultrasound assessment 14 weeks, 20 weeks, and \u226520 weeks or without antenatal ultrasound (suboptimal dating). Ultrasound-based GA information was associated with outcomes between the interest groups using chi-square tests, odds ratios (OR) with 95% CI, or the Mann-Whitney statistical analysis.<\/p>\n<\/div>\n<\/div>\n<p><strong>Results<\/strong><\/p>\n<div class=\"abstract toc-section\">\n<div id=\"section3\" class=\"section toc-section\">\n<p>The chance of nonspontaneous delivery was higher in pregnancies with 14 weeks ultrasound-based GA (OR 1.64, 95% CI 1.35-1.98) and 20 weeks ultrasound-based GA (OR 1.58, 95% CI 1.31-1.90) when compared to the pregnancies with \u226520 weeks ultrasound-based GA or without any antenatal ultrasound. The use of oxytocin for labor augmentation was higher for 14 weeks and 20 weeks ultrasound-based GA, OR 1.41 (95% CI 1.09-1.82) and OR 1.34 (95% CI 1.04-1.72), respectively, when compared to those suboptimally dated. Moreover, maternal blood transfusion after birth was more frequent in births with suboptimal ultrasound-based GA determination (20\/657, 3.04%) than in the other groups (14 weeks ultrasound-based GA: 17\/1163, 1.46%, P=.02; 20 weeks ultrasound-based GA: 25\/1456, 1.71%, P=.048). Cesarean section rates between the suboptimal dating group (244\/657, 37.13%) and the other groups (14 weeks: 475\/1163, 40.84%, P=.12; 20 weeks: 584\/1456, 40.10%, P=.20) were similar. In addition, forceps delivery rates between the suboptimal dating group (17\/657, 2.6%) and the other groups (14 weeks: 42\/1163, 3.61%, P=.24; 20 weeks: 46\/1456, 3.16%, P=.47) were similar. Neonatal intensive care unit admission was more frequent in newborns with suboptimal dating (103\/570, 18.07%) when compared with the other groups (14 weeks: 133\/1004, 13.25%, P=.01; 20 weeks: 168\/1263, 13.30%, P=.01), excluding stillbirths and major fetal malformations.<\/p>\n<\/div>\n<\/div>\n<p><strong>Conclusions<\/strong><\/p>\n<div class=\"abstract toc-section\">\n<div id=\"section3\" class=\"section toc-section\">\n<p>The present analysis highlighted relevant points of health care to improve obstetric assistance, confirming the importance of early access to technologies for pregnancy dating as an essential component of quality antenatal care.<\/p>\n<\/div>\n<\/div>\n<hr \/>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><strong>BMJ Open (Protocol)<\/strong><br \/>\n05 de mar\u00e7o de\u00a02019 \u2013 Online<\/p>\n<hr \/>\n<h3>Prematurity detection evaluating interaction between the skin of the newborn and\u00a0<span id=\"rmqId_1553138994925_381\" class=\"rmq-annotator-hl rmq-annotator-hl-temporary\">light<\/span><span id=\"rmqId_1553138994925_381\" class=\"rmq-annotator-hl rmq-annotator-hl-temporary\"><\/span>: protocol for the preemie-test multicentre clinical trial in Brazilian hospitals to validate a new medical device<\/h3>\n<p><span class=\"nlm-given-names\">Zilma Silveira Nogueira<\/span>\u00a0<span class=\"nlm-surname\">Reis,\u00a0Rodney Nascimento Guimar\u00e3es,\u00a0Maria Albertina Santiago Rego,\u00a0<span class=\"nlm-given-names\">Roberta<\/span>\u00a0Maia de Castro Romanelli, <span class=\"nlm-given-names\">Juliano de Souza<\/span>\u00a0Gaspar,\u00a0<span class=\"nlm-given-names\">Gabriela Luiza Nogueira<\/span>\u00a0Vitral,\u00a0<span class=\"nlm-given-names\">Marconi Augusto Aguiar<\/span>\u00a0dos Reis,\u00a0<span class=\"nlm-given-names\">Enrico Ant\u00f4nio<\/span>\u00a0Col\u00f3simo,\u00a0<span class=\"nlm-given-names\">Gabriela Silveira<\/span>\u00a0Neves,\u00a0<span class=\"nlm-given-names\">Marynea Silva<\/span>\u00a0Vale,\u00a0<span class=\"nlm-given-names\">Paulo de Jesus Hartamann<\/span>\u00a0Nader,\u00a0<span class=\"nlm-given-names\">Marta David Rocha<\/span>\u00a0de Moura,\u00a0<span class=\"nlm-given-names\">Regina Am\u00e9lia Pessoa Lopes<\/span>\u00a0de Aguiar<\/span><\/p>\n<p><a href=\"https:\/\/bmjopen.bmj.com\/content\/bmjopen\/9\/3\/e027442.full.pdf\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-226\" src=\"http:\/\/skinage.medicina.ufmg.br\/wp-content\/uploads\/2015\/11\/kilavuz1-1-e1490710271991.png\" alt=\"\" width=\"30\" height=\"30\" \/><\/a>\u00a0\u00a0<a href=\"https:\/\/bmjopen.bmj.com\/content\/bmjopen\/9\/3\/e027442.full.pdf\">Abrir PDF<\/a><\/p>\n<p><strong>Abstract<br \/>\n<\/strong><\/p>\n<p><strong>Introduction<\/strong><br \/>\nRecognising prematurity is critical in order to attend to immediate needs in childbirth settings, guiding the extent of medical care provided for newborns. A new medical device has been developed to carry out the preemie-test, an innovative approach to estimate gestational age (GA), based on the photobiological properties of the newborn\u2019s skin. First, this study will validate the preemie-test for GA estimation at birth and its accuracy to detect prematurity. Second, the study intends to associate the infant\u2019s skin reflectance with lung maturity, as well as evaluate safety, precision and usability of a new medical device to offer a suitable product for health professionals during childbirth and in neonatal care settings.<\/p>\n<div id=\"section1\" class=\"section toc-section\">\n<div id=\"sec-2\" class=\"subsection\">\n<p id=\"p-3\"><strong>Methods and analysis<\/strong><br \/>\nResearch protocol for diagnosis, single\u00adgroup, single\u00adblinding and single\u00adarm multicenter clinical trial with a reference standard. Alive newborns, with 24 weeks or more of pregnancy age, will be enrolled during the first 24\u2009hours of life. Sample size is 787 subjects. The primary outcome is the difference between the GA calculated by the photobiological neonatal skin assessment methodology and the GA calculated by the comparator antenatal ultrasound or reliable last menstrual period (LMP). Immediate complications caused by pulmonary immaturity during the first 72\u2009hours of life will be associated with skin reflectance in a nested case\u2013control study.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Discussion<\/strong><\/p>\n<div id=\"sec-22\" class=\"subsection\">\n<p><strong>Strengths and limitations<\/strong><br \/>\nAvailability of trustworthy GA information is a prerequisite for preterm birth classification and healthcare decisions.<a id=\"xref-ref-24-1\" class=\"xref-bibr\" style=\"font-size: 16px;\" href=\"https:\/\/bmjopen.bmj.com\/content\/9\/3\/e027442#ref-24\">24<\/a><span style=\"font-size: 16px;\">\u00a0In this light, the results of this clinical study have the potential to validate a new device for pregnancy dating. The preemie-test was prepared to operate with minimum operator intervention and for use by healthcare professionals anywhere a birth takes place without a reliable GA .<\/span><\/p>\n<p id=\"p-53\">The purpose of medical research involving neonates is intended to improve clinical procedures.<a id=\"xref-ref-25-1\" class=\"xref-bibr\" href=\"https:\/\/bmjopen.bmj.com\/content\/9\/3\/e027442#ref-25\">25<\/a>\u00a0In this context, a clinical trial is a research study in which subjects are prospectively assigned to intervention and the effects of those interventions on health-related outcomes are thereby evaluated.<a id=\"xref-ref-26-1\" class=\"xref-bibr\" href=\"https:\/\/bmjopen.bmj.com\/content\/9\/3\/e027442#ref-26\">26<\/a>\u00a0However, clinical trials on medical devices face barriers when an effective standard procedure does not exist, as is the case of the comparator procedure.<a id=\"xref-ref-27-1\" class=\"xref-bibr\" href=\"https:\/\/bmjopen.bmj.com\/content\/9\/3\/e027442#ref-27\">27<\/a>\u00a0Our challenge in preparing the present protocol was the absence of a gold standard for pregnancy dating, since the fetal age begins on conception; however, this information is difficult to be accurately determined.<a id=\"xref-ref-7-3\" class=\"xref-bibr\" href=\"https:\/\/bmjopen.bmj.com\/content\/9\/3\/e027442#ref-7\">7<\/a><\/p>\n<p id=\"p-54\">The study began with the training of health professionals in September 2018.<\/p>\n<p id=\"p-55\">Planned Date of First Enrolment: 1\u00a0February\u00a02019.<\/p>\n<p id=\"p-56\">Planned Date of Last Enrolment: 31\u00a0Decembe\u00a02019.<\/p>\n<p id=\"p-57\">Data analysis will be finalised, the results of which are expected in May 2020.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<hr \/>\n<p>&nbsp;<\/p>\n<p><strong>PLoS ONE (Research Article)<\/strong><br \/>\n26\u00a0de abril de\u00a02018 \u2013 California \u2013\u00a0US<\/p>\n<hr \/>\n<h3>Skin thickness as a potential marker of gestational age at birth despite different fetal growth profiles: A feasibility study<\/h3>\n<p>Gabriela Luiza Nogueira Vitral, Regina Am\u00e9lia P. Lopes Aguiar, Ingrid Michelle Fonseca de Souza, Maria Albertina Santiago Rego, Rodney Nascimento Guimar\u00e3es, Zilma Silveira Nogueira Reis<\/p>\n<p><a href=\"http:\/\/skinage.medicina.ufmg.br\/wp-content\/uploads\/2018\/05\/journal.pone_.0196542-Print-72dpi.pdf\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-226\" src=\"http:\/\/skinage.medicina.ufmg.br\/wp-content\/uploads\/2015\/11\/kilavuz1-1-e1490710271991.png\" alt=\"\" width=\"30\" height=\"30\" \/><\/a>\u00a0\u00a0<a href=\"http:\/\/skinage.medicina.ufmg.br\/wp-content\/uploads\/2018\/05\/journal.pone_.0196542-Print-72dpi.pdf\">Abrir PDF<\/a><\/p>\n<p><strong>Abstract<br \/>\n<\/strong><\/p>\n<p><strong>Background<\/strong><\/p>\n<div id=\"section1\" class=\"section toc-section\">\n<p>New methodologies to estimate gestational age (GA) at birth are demanded to face the limited access to obstetric ultrasonography and imprecision of postnatal scores. The study analyzed the correlation between neonatal skin thickness and pregnancy duration. Secondarily, it investigated the influence of fetal growth profiles on tissue layer dimensions.<\/p>\n<\/div>\n<p><strong>Methods and findings<\/strong><\/p>\n<div id=\"section2\" class=\"section toc-section\">\n<p>In a feasibility study, 222 infants selected at a term-to-preterm ratio of 1:1 were assessed. Reliable information on GA was based on the early ultrasonography-based reference. The thicknesses of the epidermal and dermal skin layers were examined using high-frequency ultrasonography. We scanned the skin over the forearm and foot plantar surface of the newborns. A multivariate regression model was adjusted to determine the correlation of GA with skin layer dimensions. The best model to correlate skin thickness with GA was fitted using the epidermal layer on the forearm site, adjusted to cofactors, as follows: Gestational age (weeks) = \u221228.0 + 12.8\u00a0<em>Ln<\/em>\u00a0(Thickness) \u2212 4.4 Incubator staying;\u00a0<em>R<\/em><sup>2<\/sup>\u00a0= 0.604 (P&lt;0.001). In this model, the constant value for the standard of fetal growth was statistically null. The dermal layer thickness on the forearm and plantar surfaces had a negative moderate linear correlation with GA (<em>R<\/em>\u00a0= \u22120.370, P&lt;0.001 and\u00a0<em>R<\/em>\u00a0= \u22120.421, P&lt;0.001, respectively). The univariate statistical analyses revealed the influence of underweight and overweight profiles on neonatal skin thickness at birth. Of the 222 infants, 53 (23.9%) had inappropriate fetal growths expected for their GA. Epidermal thickness was not fetal growth standard dependent as follows: 172.2 (19.8) \u03bcm for adequate for GA, 171.4 (20.6) \u03bcm for SGA, and 177.7 (15.2) \u03bcm for LGA (P = 0.525, mean [SD] on the forearm).<\/p>\n<\/div>\n<p><strong>Conclusions<\/strong><\/p>\n<div class=\"abstract toc-section\">\n<div id=\"section3\" class=\"section toc-section\">\n<p>The analysis highlights a new opportunity to relate GA at birth to neonatal skin layer thickness. As this parameter was not influenced by the standard of fetal growth, skin maturity can contribute to clinical applications.<\/p>\n<\/div>\n<\/div>\n<hr \/>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><strong>PLoS ONE (Research Article)<\/strong><br \/>\n20\u00a0de setembro de\u00a02017 \u2013 California \u2013\u00a0US<\/p>\n<hr \/>\n<h3>Newborn skin reflection: Proof of concept for a new approach for predicting gestational age at birth. A cross-sectional study<\/h3>\n<p>Zilma Silveira Nogueira Reis, Gabriela Luiza Nogueira Vitral, Ingrid Michelle Fonseca de Souza, Maria Albertina Santiago Rego, Rodney Nascimento Guimaraes<\/p>\n<p><a href=\"http:\/\/skinage.medicina.ufmg.br\/wp-content\/uploads\/2017\/09\/journal.pone_.0184734_redux.pdf\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-226\" src=\"http:\/\/skinage.medicina.ufmg.br\/wp-content\/uploads\/2015\/11\/kilavuz1-1-e1490710271991.png\" alt=\"\" width=\"30\" height=\"30\" \/><\/a>\u00a0\u00a0<a href=\"http:\/\/skinage.medicina.ufmg.br\/wp-content\/uploads\/2017\/09\/journal.pone_.0184734_redux.pdf\">Abrir PDF<\/a><\/p>\n<p><strong>Abstract<br \/>\n<\/strong><\/p>\n<p><strong>Background<\/strong><br \/>\nCurrent methods to assess the gestational age during prenatal care or at birth are a global challenge. Disadvantages, such as low accessibility, high costs, and imprecision of clinical tests and ultrasonography measurements, may compromise health decisions at birth, based on the gestational age. Newborns\u2019 organs and tissues can indirectly indicate their physical maturity, and we hypothesized that evolutionary changes in their skin, detected using an optoelectronic device meter, may aid in estimating the gestational age. This study analyzed the feasibility of using newborn skin reflectance to estimate the gestational age at birth noninvasively.<\/p>\n<p><strong>Methods and findings<\/strong><br \/>\nA cross-sectional study evaluated the skin reflectance of selected infants, preferably premature, at birth. The first-trimester ultrasound was the reference for gestational age. A prototype of a new noninvasive optoelectronic device measured the backscattering of light from the skin, using a light emitting diode at wavelengths of 470 nm, 575 nm, and 630 nm. Univariate and multivariate regression analysis models were employed to predict gestational age, combining skin reflectance with clinical variables for gestational age estimation. The gestational age at birth of 115 newborns from 24.1 to 41.8 weeks of gestation correlated with the light at 630 nm wavelength reflectance 3.3 mm\/6.5 mm ratio distant of the sensor, at the forearm and sole (Pearson\u2019s correlation = 0.505, P &lt; 0.001 and 0.710, P &lt; 0.001, respectively). The best-combined variables to predict the gold standard gestational age at birth was the skin reflectance at wavelengths of 630 nm and 470 nm in combination with birth weight, phototherapy, and adjusted to include incubator stay, and sex (R2 = 0.828, P &lt; 0.001). The main limitation of the study is that it was very specific to the premature population we studied and needs to be studied in a broader spectrum of newborns.<\/p>\n<p><strong>Conclusions<\/strong><br \/>\nA novel automated skin reflectometer device, in combination with clinical variables, was able to predict the gestational age and could be useful when the information is in doubt or is unknown. Multivariable predictive models associated the skin reflectance with easy to obtain clinical parameters, at the birth scenario. External validation needs to be proven in an actual population with the real incidence of premature infants.<\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Third WHO Global Forum on Medical Devices<\/strong><br \/>\n10 a 12 de maio de\u00a02017 \u2013 Genebra\u00a0\u2013\u00a0Su\u00ed\u00e7a<\/p>\n<hr \/>\n<h3>Prematurity detection by light<\/h3>\n<p>Prof. Zilma Reis, Rodney Nascimento Guimara\u0303es, Gabriela Lui\u0301za Nogueira Vitral, Maria Albertina Santiago Rego, Ingrid Michelle Fonseca<\/p>\n<p>Universidade Federal de Minas Gerais, Brazil<\/p>\n<p><a href=\"http:\/\/skinage.medicina.ufmg.br\/wp-content\/uploads\/2017\/06\/Poster_Preemie_test_R102_WHO-Redux-Site.pdf\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-226\" src=\"http:\/\/skinage.medicina.ufmg.br\/wp-content\/uploads\/2015\/11\/kilavuz1-1-e1490710271991.png\" alt=\"\" width=\"30\" height=\"30\" \/><\/a>\u00a0\u00a0<a href=\"http:\/\/skinage.medicina.ufmg.br\/wp-content\/uploads\/2017\/06\/Poster_Preemie_test_R102_WHO-Redux-Site.pdf\">Abrir PDF<\/a><\/p>\n<p><strong>Poster<br \/>\n<\/strong>When a baby is born very small, less than 2.5 kg, he can be premature and birth attendants need warns to timely support him and make decisions as refer the baby to the hospital. Without the critical care, the newborn viability could be neglected, as well his potential of a healthy life. The best time to determine gestational age using ultrasound is during the first three months of gestation, a difficult approach to carrying on in low-income settings. We developed a low-cost, safety, and portable optoelectronic device that can immediately estimate if the newborn is premature. The technology is based on the skin reflectance. Our solution delivers a Premie-Test that addresses one answer to support a big global health problem: the quality of care at birth, facing the doubt or unknown on the chronology of gestation. The device is easy to manufacture without high-technological support. The approach is noninvasive, automated and it can be used wherever a birth happens, by health workers and midwives in health centres or at home. Our goal is to provide a device and prepare a guidance to assist decision to face the delivery of care when the baby is born small, improving neonatal survival. Contact: <a href=\"http:\/\/skinage.medicina.ufmg.br\/index.php\/en\/\">http:\/\/skinage.medicina.ufmg.br\/index.php\/en\/<\/a>.<\/p>\n<hr \/>\n<h3>A multiband reflectance photometric device for reveal gestational age at birth<\/h3>\n<p>Prof. Rodney Guimaraes, Zilma Reis<\/p>\n<p>Universidade Federal de Minas Gerais (UFMG), Brazil<\/p>\n<p><a href=\"http:\/\/skinage.medicina.ufmg.br\/wp-content\/uploads\/2017\/06\/Poster_WHO.pdf\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-226\" src=\"http:\/\/skinage.medicina.ufmg.br\/wp-content\/uploads\/2015\/11\/kilavuz1-1-e1490710271991.png\" alt=\"\" width=\"30\" height=\"30\" \/><\/a>\u00a0\u00a0<a href=\"http:\/\/skinage.medicina.ufmg.br\/wp-content\/uploads\/2017\/06\/Poster_WHO.pdf\">Abrir PDF<\/a><\/p>\n<p><strong>Poster<\/strong><br \/>\nThis work was motivated by the desire to develop a low cost device that can immediately estimate the age of a newborn at birth.<br \/>\nThe most crucial information at birth are gestational age (GA) and weight, without this information the infant viability could be<br \/>\nneglected, as well his potential of a healthy life.<br \/>\nNowadays, the gold standard to determine the GA is the first-trimester ultrasound. However, there is a discrepancy of approx-<br \/>\nimately five to seven days with the last menstrual period, and after that time the precision of the GA information will be even<br \/>\nmore inaccurate. In addition, the ultrasound is a difficult approach to carrying on in clinical practice and considered inaccessible<br \/>\nin low-income settings.<br \/>\nOur solution addresses one answer to a low-cost technology to support a big global health problem: the quality of care at birth<br \/>\nand neonatal period, facing the doubt or unknown on the chronology of gestation. Premature newborns are more vulnerable to<br \/>\ndeath during the first days, and following days of life, severe childhood neurological disability, and lifelong complications.<\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><strong>X Congresso Mineiro de Ginecologia e Obstetr\u00edcia<\/strong><br \/>\n10 a 13 de maio de\u00a02017 \u2013 Belo Horizonte \u2013 Brasil<\/p>\n<hr \/>\n<h3>Avalia\u00e7\u00e3o da idade gestacional no momento do parto por diferentes referenciais cl\u00ednicos: um desafio atual<\/h3>\n<p>Ingrid Michelle F. de Souza\u00b9 , Carolina N. de S\u00e3o Jos\u00e9\u00b3, Paola C. Silva\u00b2, Gabriela L. N. Vitral\u00b9, Wagner B. Magalh\u00e3es\u00b9, Maria Albertina S. Rego\u00b9, Rodney N. Guimar\u00e3es\u00b9, Zilma S. N. Reis\u00b9<\/p>\n<p>\u00b9Faculdade de Medicina da Universidade Federal de Minas Gerais; \u00b2Hospital Sofia Feldman; \u00b3Faculdade de Ci\u00eancias M\u00e9dicas de Minas Gerais<\/p>\n<p><a href=\"http:\/\/skinage.medicina.ufmg.br\/wp-content\/uploads\/2017\/05\/unnamed.jpg\" target=\"_blank\" rel=\"noopener noreferrer\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-337 size-full\" src=\"http:\/\/skinage.medicina.ufmg.br\/wp-content\/uploads\/2015\/11\/Sem-T\u00edtulo-1.png\" alt=\"\" width=\"30\" height=\"30\" \/><\/a>\u00a0\u00a0<a href=\"http:\/\/skinage.medicina.ufmg.br\/wp-content\/uploads\/2017\/05\/unnamed.jpg\" target=\"_blank\" rel=\"noopener noreferrer\">Abrir\u00a0Poster<\/a><\/p>\n<p><strong>Introdu\u00e7\u00e3o<br \/>\n<\/strong>A cronologia da gesta\u00e7\u00e3o \u00e9 o principal marcador de sobrevida do rec\u00e9m nascido e acredita-se que sua determina\u00e7\u00e3o precisa afeta os resultados perinatais. A informa\u00e7\u00e3o correta da idade gestacional (IG) permite que a gravidez seja conduzida adequadamente, al\u00e9m de fundamentar interven\u00e7\u00f5es neonatais apropriadas. Al\u00e9m disso, \u00e9 a base para a estat\u00edstica de prematuridade, orientando pol\u00edticas p\u00fablicas. Os m\u00e9todos atuais de estimativa da IG dependem da data da \u00faltima menstrua\u00e7\u00e3o (DUM), muitas vezes incerta, ou desconhecida ou de prefer\u00eancia de um ultrassom (US), realizado no primeiro trimestre da gravidez, o que nem sempre \u00e9 acess\u00edvel.<strong><br \/>\n<\/strong><\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><strong>XV Congresso Brasileiro de Inform\u00e1tica em Sa\u00fade<\/strong><br \/>\n27 a 30 de novembro de 2016 \u2013 Goi\u00e2nia \u2013 Brasil<\/p>\n<hr \/>\n<h3>Meu Pr\u00e9-natal \u2013 Aplicativo para dispositivos m\u00f3veis<\/h3>\n<p>Marcelo R Santos Jr\u00b9 , Dimitri Santos\u00b9 , Isaias J R Oliveira\u00b9 , Zilma Reis\u00b9<br \/>\n\u00b9Faculdade de Medicina da UFMG, Belo Horizonte, MG<\/p>\n<p><a href=\"http:\/\/www.sbis.org.br\/biblioteca_virtual\/cbis\/Anais_CBIS_2016_Diversos.pdf#page=86\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-226\" src=\"http:\/\/skinage.medicina.ufmg.br\/wp-content\/uploads\/2015\/11\/kilavuz1-1-e1490710271991.png\" alt=\"\" width=\"30\" height=\"30\" \/><\/a>\u00a0\u00a0<a href=\"http:\/\/www.sbis.org.br\/biblioteca_virtual\/cbis\/Anais_CBIS_2016_Diversos.pdf#page=86\">Abrir PDF<\/a><\/p>\n<p><strong>Resumo<br \/>\n<\/strong>Uma nova forma de comunica\u00e7\u00e3o entre os profissionais de sa\u00fade e seus pacientes adv\u00e9m da populariza\u00e7\u00e3o dos dispositivos m\u00f3veis e dos aplicativos de apoio ao cuidado. Esta demonstra\u00e7\u00e3o apresenta um aplicativo para o uso em dispositivos m\u00f3veis, capaz de subsidiar informa\u00e7\u00f5es relevantes sobre a gesta\u00e7\u00e3o, parto e amamenta\u00e7\u00e3o, de forma a contribuir para o processo de educa\u00e7\u00e3o em sa\u00fade para as mulheres. Desenvolvido por uma equipe multidisciplinar acad\u00eamica em uma universidade p\u00fablica, o aplicativo j\u00e1 se encontra dispon\u00edvel gratuitamente e o usu\u00e1rio-alvo s\u00e3o as gestantes e pu\u00e9rperas. O aplicativo Meu Pr\u00e9-natal proporciona informa\u00e7\u00f5es confi\u00e1veis sobre cuidados na gravidez, parto e puerp\u00e9rio, incentivando o cuidado pr\u00e9-natal e de forma complementar ao cuidado do profissional de sa\u00fade, sem jamais substitu\u00ed-lo. Disponibiliza textos com linguagem acess\u00edvel ao p\u00fablico leigo, imagens e v\u00eddeo, com interface que permite navega\u00e7\u00e3o f\u00e1cil e intuitiva entre seus m\u00f3dulos. Acredita-se que o projeto seja capaz de apoiar a gestante e seu beb\u00ea no centro da aten\u00e7\u00e3o pr\u00e9-natal, permitindo uma participa\u00e7\u00e3o mais ativa e que ofere\u00e7a informa\u00e7\u00f5es e funcionalidades que a apoiar\u00e3o durante toda sua gravidez, parto e p\u00f3s-parto.<\/p>\n<p><strong>Palavras-chave<br \/>\n<\/strong>Aplicativo, Educa\u00e7\u00e3o em sa\u00fade, Pr\u00e9-natal, Rela\u00e7\u00f5es Comunidade-Institui\u00e7\u00e3o, Dispositivos m\u00f3veis.<\/p>\n<hr \/>\n<h3>Determina\u00e7\u00e3o autom\u00e1tica da espessura da epiderme em imagens ultrassonogr\u00e1ficas<\/h3>\n<p>Gabriela Vitral\u00b9 , Michelle Fonseca\u00b9 , Wagner Magalh\u00e3es\u00b9 , Rodney Guimar\u00e3es\u00b9 , Zilma Reis\u00b9<br \/>\n\u00b9Faculdade de Medicina da Universidade Federal de Minas Gerais, UFMG, Belo Horizonte, MG<\/p>\n<p><a href=\"http:\/\/www.sbis.org.br\/biblioteca_virtual\/cbis\/Anais_CBIS_2016_Diversos.pdf#page=205\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-226\" src=\"http:\/\/skinage.medicina.ufmg.br\/wp-content\/uploads\/2015\/11\/kilavuz1-1-e1490710271991.png\" alt=\"\" width=\"30\" height=\"30\" \/><\/a>\u00a0\u00a0<a href=\"http:\/\/www.sbis.org.br\/biblioteca_virtual\/cbis\/Anais_CBIS_2016_Diversos.pdf#page=205\">Abrir PDF<\/a><\/p>\n<p><strong>Resumo <\/strong><br \/>\nA estimativa das dimens\u00f5es de \u00f3rg\u00e3os humanas atrav\u00e9s de imagens m\u00e9dicas trouxe avan\u00e7os importantes no diagn\u00f3stico de doen\u00e7as. A automa\u00e7\u00e3o de medidas tem o potencial de reduzir interfer\u00eancias examinador-dependentes. O objetivo desse estudo foi desenvolver um software para estimar automaticamente a espessura da epiderme humana, a partir de uma imagem obtida por ultrassom. O software foi desenvolvido em linguagem Phyton, sendo capaz de detectar as bordas irregulares da epiderme e estimar sua espessura utilizando uma t\u00e9cnica estat\u00edstica conhecida como bootstrap. Foram realizados testes em 90 imagens. O software se mostrou pr\u00e1tico e satisfat\u00f3rio para profssionais de sa\u00fade, possibilitando sua utiliza\u00e7\u00e3o de forma racional e oportuna na medida indireta da espessura da epiderme humana.<\/p>\n<p><strong>Palavras-chave<\/strong><br \/>\nPele; Software; Inform\u00e1tica M\u00e9dica; Diagnostico por imagem.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>JMIR Publications (Research Article) 14\u00a0de julho de\u00a02020 \u2013 Toronto\u2013\u00a0Canada Premature or Small for Gestational Age Discrimination: International Multicenter Trial Protocol for Classification of the Low-Birth-Weight Newborn Through the Optical Properties of the Skin Zilma Reis, Gabriela Vitral, Rodney Guimar\u00e3es, Juliano Gaspar, Enrico Colosimo, Sergio Taunde, Nilza Mussagy, Rita Rosado Santos, Diogo Ayres-De-Campos, Roberta Romanelli \u00a0\u00a0Abrir<a href=\"https:\/\/skinage.medicina.ufmg.br\/index.php\/en\/scientific-papers\/\">[&#8230;]<\/a><\/p>\n","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"jetpack_post_was_ever_published":false,"footnotes":""},"class_list":["post-67","page","type-page","status-publish","hentry"],"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/P8xxvS-15","_links":{"self":[{"href":"https:\/\/skinage.medicina.ufmg.br\/index.php\/wp-json\/wp\/v2\/pages\/67","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/skinage.medicina.ufmg.br\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/skinage.medicina.ufmg.br\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/skinage.medicina.ufmg.br\/index.php\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/skinage.medicina.ufmg.br\/index.php\/wp-json\/wp\/v2\/comments?post=67"}],"version-history":[{"count":11,"href":"https:\/\/skinage.medicina.ufmg.br\/index.php\/wp-json\/wp\/v2\/pages\/67\/revisions"}],"predecessor-version":[{"id":751,"href":"https:\/\/skinage.medicina.ufmg.br\/index.php\/wp-json\/wp\/v2\/pages\/67\/revisions\/751"}],"wp:attachment":[{"href":"https:\/\/skinage.medicina.ufmg.br\/index.php\/wp-json\/wp\/v2\/media?parent=67"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}